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Pericardial Mesothelioma

Pericardial mesothelioma is the rarest form of mesothelioma, accounting for less than 1% of all cases. It develops in the pericardium, the protective sac surrounding the heart. Due to its rarity and location, it is frequently diagnosed postmortem and carries the poorest prognosis of all mesothelioma types.

Pericardial mesothelioma develops in the pericardial membrane that encases the heart. The exact mechanism by which asbestos fibers reach the pericardium is not fully understood, though researchers believe fibers may travel through the bloodstream or lymphatic system from the lungs.

Symptoms include chest pain, heart palpitations, shortness of breath, and cardiac tamponade (fluid compressing the heart). Because these symptoms mimic common cardiac conditions, diagnosis is extremely difficult. Many cases are only confirmed through biopsy or during autopsy.

Treatment options are limited due to the tumor's proximity to the heart. Palliative approaches — including pericardiocentesis to drain fluid and radiation therapy — are most common. Patients diagnosed with pericardial mesothelioma should explore all available options, including clinical trials and legal compensation.

Quick Facts
Also known as
Malignant pericardial mesothelioma
Category
Medical
ICD-10 Code
C45.2
Learn More
Common Questions
How rare is pericardial mesothelioma?

Pericardial mesothelioma accounts for less than 1% of all mesothelioma cases. Due to its rarity and location near the heart, it is frequently diagnosed postmortem.

What are the symptoms of pericardial mesothelioma?

Symptoms include chest pain, heart palpitations, shortness of breath, and cardiac tamponade. These often mimic common cardiac conditions, making diagnosis difficult.

Source: National Cancer Institute (NCI)
Reviewed by Paul Danziger, J.D. ·

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