The most common place for mesothelioma to develop is in the mesothelial membrane, also called the pleural lining, surrounding the lungs. About two-thirds of all mesothelioma cases develop in the pleural mesothelium or lung lining. Pleural mesothelioma is also known as cancer of the lung lining.

The remaining cases, about one-third, develop in the peritoneal mesothelium in the abdomen (peritoneal mesothelioma). Rarely, mesothelioma occurs in other mesothelial tissue, such as around the heart or in the reproductive organs (pericardial mesothelioma).

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